- Title
- Catheter-based renal sympathetic denervation for resistant hypertension durability of blood pressure reduction out to 24 months
- Creator
- Symplicity HTN-1 Investigators,; Thambar, Suku; Nanra, Ranjit S.
- Relation
- Hypertension Vol. 57, Issue 5, p. 911-917
- Publisher Link
- http://dx.doi.org/10.1161/hypertensionaha.110.163014
- Publisher
- American Heart Association
- Resource Type
- journal article
- Date
- 2011
- Description
- Renal sympathetic hyperactivity is seminal in the maintenance and progression of hypertension. Catheter-based renal sympathetic denervation has been shown to significantly reduce blood pressure (BP) in patients with hypertension. Durability of effect beyond 1 year using this novel technique has never been reported. A cohort of 45 patients with resistant hypertension (systolic BP ≥160 mm Hg on ≥3 antihypertension drugs, including a diuretic) has been originally published. Herein, we report longer-term follow-up data on these and a larger group of similar patients subsequently treated with catheter-based renal denervation in a nonrandomized manner. We treated 153 patients with catheter-based renal sympathetic denervation at 19 centers in Australia, Europe, and the United States. Mean age was 57±11 years, 39% were women, 31% were diabetic, and 22% had coronary artery disease. Baseline values included mean office BP of 176/98±17/15 mm Hg, mean of 5 antihypertension medications, and an estimated glomerular filtration rate of 83±20 mL/min per 1.73 m2. The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to ≥2 years of follow-up, without significant adverse events.
- Subject
- hypertension; blood pressure; renal sympathetic denervation
- Identifier
- http://hdl.handle.net/1959.13/1044465
- Identifier
- uon:14331
- Identifier
- ISSN:0194-911X
- Language
- eng
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